Peptides

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Pharmacokinetic Data

Retatrutidesingle · t½ ~6 days

Long-acting GLP-1/GIP/GCGR tri-agonist. Weekly dosing; doses stack.

Phase 2 NEJM trial (Jastreboff 2023) reports half-life of ~6 days. Consistent across multiple sources. Weekly dosing means significant accumulation (~48% remaining at trough).

Source 1Source 2
CPC 1295 / Ipamorelin Blendblend · t½ CJC-1295 (no DAC): ~30 min, Ipamorelin: ~2 hours

GH secretagogue blend. Both constituents clear within hours.

CJC-1295 without DAC (mod GRF 1-29) has a short half-life of ~30 minutes (Teichman 2006). Ipamorelin half-life ~2 hours based on Raun 1998 pharmacokinetic data. Both are GH secretagogues with rapid clearance.

Source 1Source 2

Data source: peptide-pharmacokinetics.json

To add a new peptide, run /research-peptide-pharmacokinetics PeptideName in Claude Code.